Is Metal Ion Release also a Concern for Ceramic-on-Ceramic Couplings?

Some metal-on-metal hip devices that are known to release chromium and cobalt metal ions have been shown to produce toxicological effects. BIOLOX®delta, however, also contains trivalent chro- mium ions, which randomly replace the trivalent aluminum ions in the alumina matrix. Despite being strongly bound to the alumina lattice, it has yet to be experimentally proven if the chromium ions are eventually released into the body. If BIOLOX®delta is completely biocompatible in terms of ion release, it could offer an excellent alternative to metal-based bearing couples.

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